The NETTER-1 trials led to the approval of Lu177 (or Lutathera), more commonly known in the community as Peptide Receptor Radio Therapy (PRRT). This led to an explosion of availability across the world but many gaps in service remain.
Many PRRT spin off trials are in the pipeline looking at different types of PRRT, mainly using slightly different radionuclides and techniques. However, NETTER-2 builds on the success of the approved version formally known as Lutathera.
The aim of NETTER-2 is to determine if Lutathera in combination with long-acting octreotide prolongs PFS in GEP-NET patients with high proliferation rate tumors (G2 and G3), when given as a first line treatment compared to treatment with high dose (60 mg) long-acting octreotide. Somatostatin analog (SSA) naive patients are eligible, as well as patients previously treated with SSAs in the absence of progression.
This is a phase 3 trial that will be hoping for 222 participants at multiple locations.
This article will be fleshed out in due course. No locations listed yet. Not recruiting yet. Criteria listed – important section if this trial interests you. Clinical Trials document here.
In the meantime, read more about Lutathera (PRRT) by clicking here.
This looks like a very exciting development.
Thanks for reading