Tag: Apudoma

GI NETs are also classified as APUDomas (amine precursor uptake and decarboxylation), as are medullary thyroid carcinomas, melanomas, and pheochromocytomas, because they share various cytochemical, pathologic, and biologic features (Klimstra, 2016). These tumours were originally proposed to have a common embryonic origin from neural crest cells but subsequent studies showed that this was not the case. All NETs share a number of common features (Klimstra, 2016). However, the different clinical syndromes have important differences and there are a number of differences between GI NETs and panNETs. This term is no longer used in Neuroendocrine Neoplasm classifications.

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Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies (incl NET)

Trial Summary This interesting trial is a multi-cancer effort including NET. The phase I clinical trial of Procaspase Activating Compound-1 (PAC-1), a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers. The drug stalled the growth of tumors in the five people in the trial […]

Dustin Diamond

I’m behind the curve on this one after being ahead on celebrities such as Steve Jobs, Aretha Franklin, Wilko Johnson and Olivia Williams. But in my defence, Dustin Diamond was not that well known in UK. I noticed his name mentioned in relation to “Neuroendocrine” in early 2023. I set about searching and it didn’t […]

Neuroendocrine tumors are uncommon but definitely not rare

USA finally commits UK and Australian figures recently confirmed that Neuroendocrine Cancer is the 10th and 7th most common cancer type. It was great to see this post from the American Society of Clinical Oncology, albeit the USA is joining later than many other countries confirming the worst-kept secret ever – NETs are not rare. […]

Cancer Ablation

What is Cancer Ablation? This is a minimally invasive surgical method to treat solid cancers. Special probes are used to “burn” or “freeze” cancers. Computed Tomography (CT), Ultrasound (US) or Magnetic Resonance Imaging (MRI) is used to guide and position the needle probe into the tumour. This requires only a tiny hole, usually less than […]

Lactose intolerance – the NET Effect

Background When I cast my mind back to my very first surgery, I remember asking my Oncologist what I could do to put on weight. He said to drink full-fat milk. I was compliant in those days without reverting to Dr Google. Anyway, I did put on weight but perhaps the milk played a small […]