GI NETs are also classified as APUDomas (amine precursor uptake and decarboxylation), as are medullary thyroid carcinomas, melanomas, and pheochromocytomas, because they share various cytochemical, pathologic, and biologic features (Klimstra, 2016). These tumours were originally proposed to have a common embryonic origin from neural crest cells but subsequent studies showed that this was not the case. All NETs share a number of common features (Klimstra, 2016). However, the different clinical syndromes have important differences and there are a number of differences between GI NETs and panNETs. This term is no longer used in Neuroendocrine Neoplasm classifications.
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