TraceNETTM is a a novel copper-based ‘radiodiagnostic’ for detecting neuroendocrine tumours (NET). The PET imaging agent candidate is the diagnostic component of NUCLIDIUM’s theranostic program, which comprises a true theranostic pair for diagnosing and treating NET patients, leveraging the company’s unique copper-based approach. The Phase 1 program for the diagnostic is the first step in its clinical development and is planned to commence in the first half of 2023.
Nuclidium’s TraceNETTM program aims to overcome key limitations of existing radiodiagnostics and their corresponding therapeutics by increasing the sensitivity and diagnostic accuracy of NET imaging, including detecting metastases, while reducing the radiation burden for the patient. The TraceNETTM diagnostic consists of an imaging radioisotope (61Cu) and a somatostatin receptor (SSTR) antagonist-targeting molecule that binds with high affinity and specificity to SSTRs overexpressed on the surface of most NET cells.
NUCLIDIUM announced that the Neuroendocrine Tumors Research Foundation (NETRF) has selected the company and its collaboration partner the University Hospital Basel as recipients of its Investigator Award. The grant will support the initiation and execution of a Phase 1 clinical trial with TraceNETTM The Investigator Award is granted to one or two applicants each year and supports projects for two years.
The Phase 1 study will assess the safety, biodistribution, pharmacokinetics and dosimetry of TraceNETTM in NET patients. It will also analyse the performance of TraceNETTM in PET/CT imaging compared to 68Ga-DOTATOC, one of the current state-of-the-art imaging agents for the detection of NET in the same patients.
As technology moves on, scientists must look for more efficient diagnostics and therapies for NET. Ga68 based PET scans were a revolution in NET diagnostics in the same way Peptide Receptor Radionuclide Therapy (PRRT) using Lutathera (Lu177) was in therapy. But Nuclidium’s ‘theranostic approach’ provides a copper-based platform enables an easy adjustment of each product candidate from a diagnostic to a therapeutic by simply exchanging 61Cu with 67Cu.
Information is sparse but I will build up this post in due course
1. ClinicalTrials.gov Identifier – to follow (likely to be Switzerland initially)
2. NET Research Foundation announcement – to follow.
3. Nuclidium’s copper based theranostic platforms – click here
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided in the clinical trials document. It’s very important to check the trial inclusion and exclusion criteria before making any contact. If you need questions, the articles here is very useful Questions to Ask About Clinical Trials | Cancer.Net
The inclusion of any trial within this blog should not be taken as a recommendation by Ronny Allan.
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