Cancer-related fatigue (CRF) – Neuroendocrine Cancer

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 14.2K other subscribers

In my patient support group of 8000+, fatigue is very commonly discussed, and it certainly gets bags of empathy from the readers.  I remember being really tired in the first few years after my diagnosis and in the years preceding it. As I was very focused on my work in those days, I was putting it down to the rigours of my working practices, commuting, overnighting, and working far too many hours in a day.  In 2010, my diagnosis was triggered by symptoms of iron deficiency anaemia which was almost certainly connected to my cancer and feelings of fatigue for quite a while leading up to the diagnosis.  That said, I gradually got back into old ways after diagnosis and pretty much continued to put my tiredness down to the same old excuse.  It was around 3 years after my diagnosis that I pulled my head out of the sand and started working out how to improve my quality of life.

Spotting the difference between regular fatigue/tiredness and cancer-related fatigue (CRF)

This is not an exact science so let’s start with a definition of Fatigue.  According to Mayo Clinic “Nearly everyone is overtired or overworked from time to time. Unrelenting exhaustion, on the other hand, lasts longer, is more profound and isn’t relieved by rest. It’s a nearly constant state of weariness that develops over time and reduces your energy, motivation and concentration. Fatigue at this level also impacts your emotional and psychological well-being.

I like Mayo’s opening statement “Taking an honest inventory of things that might be responsible for your fatigue is often the first step toward relief”. I think NET patients need to not immediately assume it’s solely the NET at this point and use this tick list – even NET patients get regular illnesses or they at least might be contributing.  Over my lifetime, way before I had NETs, I can certainly tick most of these at some point and one or two of them today.  Fatigue may be related to:

  1. Alcohol or drug use
  2. Excess physical activity
  3. Jet lag disorder
  4. Lack of physical activity
  5. Medications, such as antihistamines, cough medicines
  6. Not enough sleep
  7. Unhealthy eating habits

I suspect these 7 points are the most common and others may apply.  Fatigue is generally defined as extreme tiredness that results from mental or physical exertion, or illness.  Everyone will experience fatigue at some point as it is simply the body’s natural way of showing that rest is needed. However, exhaustion that lasts for prolonged periods of time is not normal.

Cancer-related fatigue (CRF)

This is different from the fatigue of daily life and many studies have shown a clear linkage between cancer and fatigue.   It is more severe than regular fatigue and is often described as an overwhelming exhaustion that cannot be overcome with a good night’s rest. Some people may also describe it as constantly feeling physically weak, drained or have difficulty concentrating (“brain fog”). If you look at many cancer sites, fatigue is listed as a symptom but for many different cancers, there may in some cases be different causal effects. I intend to open that up more below to cover some of the main issues related to NETs.

Below are some signs of CRF that you should pay close attention to. If more than one of the following symptoms apply to you, I recommend visiting your doctor.

  • Weakness or tiredness that lasts for longer than 2 weeks
  • Weakness or tiredness accompanied by a loss of weight
  • Tiredness that remains even after rest or sleep, it keeps coming back, or is getting worse.
  • You are continually finding yourself more tired than usual or breathless during or after an activity.
  • You’re spending extra time in bed and/or sleeping for unusual amounts of time.
  • You are finding it significant difficulty to concentrate and becoming confused more easily.

The causes of cancer-related fatigue (CRF)

I found the site very useful in this part of my research.  This award-winning site is maintained by a group of oncology healthcare professionals, so they know what they are talking about.

According to them, the most common reason for CRF is anaemia, something which will be of interest to many NET patients.  As I said above, I was actually diagnosed via iron deficiency anaemia signalled by low haemoglobin results. Anaemia prevents bone marrow from efficiently producing red blood cells. Since red blood cells contain ‘haemoglobin’, which carries oxygen from the lungs to the body’s cells, a deficiency of red blood cells means there is less oxygen being carried around the body.  Your body’s cells use the oxygen to fuel the combustion of sugar and fat, which then produces the body’s energy, and so, without oxygen, the body cannot function properly, and this leads to the feelings of extreme tiredness.  The other causes listed by OncoLink are included below alongside anaemia (some entries supplemented from ASCO):

Medical conditions that can cause fatigue

  • Anaemia.  Many NET patients will have anaemia as a side effect their NET type e.g. Gastric NETs are known to be associated with pernicious anaemia. Small Intestine NETs with iron deficiency anaemia. There are many other anaemia related scenarios.
  • Pain.  The physical and emotional energy you use trying to deal with pain can make you feel fatigued including loss of sleep, and it can also force you to be less mobile.
  • Infection.  e.g. You sleep a lot when you have flu. SIBO in small intestine NETs or those who have had bowel surgery, might contribute.
  • Cardiac (heart) or pulmonary (lung) disease.   Can affect blood flow in the body or cause inflammation and may lead to fatigue.
  • Medication side effect.  As one example, I always feel sleepy if I take antihistamines and certain cough medicines.  I know fatigue is listed as a short-term side effect of somatostatin analogues (in my own experience that improved over time).  Treatments, including chemotherapy, immunotherapy, targeted therapy and radiation therapy; are known to cause fatigue, mostly while undergoing treatment.
  • Endocrine disorders. Not having enough thyroid hormone can slow down a person’s metabolism and lead to several adverse symptoms. This is a very common issue in the general population, but somatostatin analogues are known to affect thyroid levels in some NET patients (or exacerbate an existing comorbidity).  Diabetes can contribute to fatigue and is a common issue in the general population.  Many functional pancreatic NETs can succumb to diabetes (or exacerbate an existing comorbidity) due to their cancer type and some NET treatments can influence blood glucose levels, including but not limited to, somatostatin analogues.
  • Nutritional deficiency.  Nutrition is a huge issue for many NET patients, particularly those who have had surgery and have known functional tumours where the oversecretion of hormones is causing these deficiencies. NET patients are known to be at risk for several vitamins and minerals many of which are related to low energy for tiredness and might have been caused by malabsorption. ASCO added this could be an issue with electrolyte imbalances, such as abnormal levels of sodium, potassium, calcium, and magnesium.  You may need to involve a registered dietitian in helping to assess and then treat these causes of fatigue.
  • Renal (kidney) failure. Can lead to a build-up of toxins and impurities in the blood causing people to feel tired, weak and can make it hard to concentrate.  This issue can also cause anaemia.

But it’s not just medical conditions according to OncoLink and ASCO. Psychosocial conditions that can cause fatigue

  • Lack of family, friends, and community social supports.
  • Poor coping skills.
  • Sedentary lifestyle.
  • Anxiety.
  • Depression.
  • Sleep problems; especially a lack of sleep or disrupted sleep patterns.

There’s a useful article from American Society of Clinical Oncology (ASCO) entitled Cancer-Related Fatigue: What People With Cancer and Their Loved Ones Should Know | Cancer.Net

How can we help relieve or prevent cancer-related fatigue?

I am far from qualified to advise you on this but according to OncoLink, ” …………. only two interventions have been proven truly effective in large clinical trials to relieve or prevent fatigue: correction of anaemia and exercise. One reason it has been difficult to evaluate new therapies is due to a lack of understanding of the exact cause of CRF, as well as the lack of an animal model in which to do preliminary studies. You can’t exactly ask a mouse to rate his fatigue!”.  In addition to anaemia and exercise, OncoLink does discuss some other ways to manage fatigue that have been shown to be helpful (the link is below).

I also liked the page from the American Society of Clinical Oncology (ASCO) “8 Ways to Cope With Cancer-Related Fatigue” – read more here.

And I also like this advice from ASCO here – 
How to Improve Cancer-Related Fatigue Using Exercise: Expert Perspectives

When should I be concerned?

It is important to remember that many different things can cause fatigue and/or anaemia, and more commonly it can be explained by lack of sleep, long hours at work, hormone imbalances, anxiety, depression or dietary deficiencies. As a general rule, if your level of tiredness is affecting your ability to function properly and is persisting for an unusual length of time, visit your doctor to gain professional opinion and rule out any underlying problem. Knowing what other symptoms are typical of NET is crucial for helping you make the decision to visit your doctor sooner.


I am not a doctor or any form of medical professional, practitioner or counsellor. None of the information on my website, or linked to my website(s), or conveyed by me on any social media or presentation, should be interpreted as medical advice given or advised by me. 

Neither should any post or comment made by a follower or member of my private group be assumed to be medical advice, even if that person is a healthcare professional.   

Please also note that mention of a clinical service, trial/study or therapy does not constitute an endorsement of that service, trial/study or therapy by Ronny Allan, the information is provided for education and awareness purposes and/or related to Ronny Allan’s own patient experience. This element of the disclaimer includes any complementary medicine, non-prescription over the counter drugs and supplements such as vitamins and minerals.

Click picture to subscribe

Thanks for reading.


Personal Facebook. Like this page please.
Blog Facebook. Like this page please.
Awareness Facebook Like this page please.

Sign up for my newsletters – Click Here


My Diagnosis and Treatment History

Follow me on twitter

Check out my online presentations

Check out my WEGO Health Awards

Check out my Glossary of Terms – click here

patients included

Please Share this post for Neuroendocrine Cancer awareness and to help another patient


A cup of tea

I would also mention those who contributed to my “Tea Fund” which resides on PayPal.  You don’t need a PayPal account as you can select a card but don’t forget to select the number of units first (i.e. 1 = £4, 2 = £8, 3 = £12, and so on), plus further on, tick a button to NOT create a PayPal account if you don’t need one.  Clearly, if you have a PayPal account, the process is much simpler 

Through your generosity, I am able to keep my sites running and provide various services for you.  I have some ideas for 2023 but they are not detailed enough to make announcements yet. 

This screenshot is from every single post on my website and depending on which machine you are using, it will either be top right of the post or at the bottom (my posts are often long, so scroll down!)

One thought on “Cancer-related fatigue (CRF) – Neuroendocrine Cancer

  • Isabel

    This is really useful validation, Ronny. It’s all so familiar to my life since diagnosis ten (ten!) years ago. I think I can tick every box/possible cause you mention. As ever, a million thanks.

I love comments - feel free!

%d bloggers like this:
Verified by MonsterInsights