
Summary Great start to 2023 and I thank those who continue to support my social media and this blog. I’m keen to hear any suggestions of the sort of thing you would like me to research and publish. The top 10 most-read posts in January are listed below: Paul Hunter Tribute – Snooker champion and […]

Trial Summary This interesting trial is a multi-cancer effort including NET. The phase I clinical trial of Procaspase Activating Compound-1 (PAC-1), a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers. The drug stalled the growth of tumors in the five people in the trial […]

I’m behind the curve on this one after being ahead on celebrities such as Steve Jobs, Aretha Franklin, Wilko Johnson and Olivia Williams. But in my defence, Dustin Diamond was not that well known in UK. I noticed his name mentioned in relation to “Neuroendocrine” in early 2023. I set about searching and it didn’t […]

USA finally commits UK and Australian figures recently confirmed that Neuroendocrine Cancer is the 10th and 7th most common cancer type. It was great to see this post from the American Society of Clinical Oncology, albeit the USA is joining later than many other countries confirming the worst-kept secret ever – NETs are not rare. […]

What is Cancer Ablation? This is a minimally invasive surgical method to treat solid cancers. Special probes are used to “burn” or “freeze” cancers. Computed Tomography (CT), Ultrasound (US) or Magnetic Resonance Imaging (MRI) is used to guide and position the needle probe into the tumour. This requires only a tiny hole, usually less than […]
Ronny-
Immunotherapy on the site?
I was diagnosed with stage 4 pancreatic NET mets to liver in Jan 2019. After a few weeks with a 3-6 mo survival diagnosis some additional tumor analysis found they were Hi-MSI tumors -eligible to be treated with recently approved (for all Hi MSI solid tumors) immunotherapy.
I had great results being treated with ipilumumab + nivolumab for 24 mos. Tumors shrunk to about 10% of the original mass and then were stable for a couple more months. Once the tumors started growing (slowly) again, I came off the original treatment and have been on investigational immunotherapy since. First trail was successful for 3-6 mos. Now I’m onto the 2nd trial and feeling better again.
With an FDA approved immunotherapy for Hi-MSI NETs, suggest it would be useful to have info about immunotherapy on your site. I was treated at MD Anderson in Houston.
The team at MD Anderson almost immediately did tumor analysis that flagged the biomarkers which showed immunotherapy would likely be effective. Suspect not all patients have that good fortune.
Let me know if I can help.
-P
What is your grade and differentation?
The immunotherapy experience with Neuroendocrine Neoplasms is not great, there’s always outliers of course.