Somatostatin Analogues for Neuroendocrine Cancer: Lanreotide and Octreotide

Somatostatin Analogues are the ‘workhorse’ treatments for those living with NETs, particularly where certain syndromes are involved.  So not just for classic NETs with Carcinoid Syndrome but also for treating the hormone overscretions caused by insulinoma, gastrinoma, glucagonoma and VIPoma (all types of pNETs) and others. They are most effective if the NETs express somatostatin receptors.  They also have an anti-tumour effect but more of a slowing down of growth rather than a killing or reduction of tumour size – but there are always outliers where such effects are displayed.

Somatostatin is actually a naturally occurring hormone produced by the hypothalamus and some other tissues such as the pancreas and the gastrointestinal tract. However, it can only handle the normal release of hormones.  When NET syndromes occur, the naturally occurring somatostatin is unable to cope. The word ‘analogue’ in the simplest of terms, means ‘manufactured’ and a somatostatin analogue is made to be able to cope with the excess secretion (in most cases).

Although there is hidden complexity, the concept of the drug is fairly simple.  It can inhibit insulin, glucagon, serotonin, VIP, it can slow down bowel motility and increase absorption of fluid from the gut. It also has an inhibitory effect on growth hormone release from the pituitary gland (thus why it’s also used to treat a condition called Acromegaly). You can see why it’s a good treatment for those with NET syndromes, i.e. who suffer from the excess secretions of hormones from their NETs.  Clearly there can be side effects as it also inhibits digestive enzymes which can contribute to, or exacerbate, gastro-intestinal malabsorption.

Please note somatostatin analogues are not chemotherapy.  There are two major types in use:

  • Octreotide – or its brand name Sandostatin.  It is suffixed by LAR for the ‘long acting release’ version.
  • Lanreotide – brand name Somatuline (suffixed by ‘Depot’ in North America, ‘Autogel’ elsewhere)
There’s a third but it has not made much headway in mainstream NETs.  Read about Pasireotide by clicking here

So what’s the difference between the two?

A frequently asked question. Here’s a quick summary:

  • They are made by two different companies.  Novartis manufactures Octreotide and Ipsen manufactures Lanreotide.  Octreotide has been around for much longer.
  • The long-acting versions are made and absorbed very differently.  Octreotide has a complex polymer and must be injected in the muscle to absorb properly.  Lanreotide instead uses has a novel nanotube structure and is water based (click here to see a video of how this works). It is injected deep-subcutaneously and is, therefore, easier to absorb and is not greatly impacted if accidentally injected into muscle.
  • Their delivery systems are mainly via injections but are fundamentally different.  Octreotide long-acting requires a pre-mix, whilst Lanreotide comes pre-filled. Please note that Ipsen is rolling out a new Lanreotide delivery system.  You can read a review entitled “An International Simulated Use Study (PRESTO) to Evaluate Nurse Preferences Between the Lanreotide Autogel New Syringe and Octreotide Long-Acting Release Syringe”click here.
  • The long-acting versions are 60, 90 and 120 mg for Lanreotide and 10, 20 and 30 mg for Octreotide.
  • Octreotide also has a daily version (or rescue shot) which is administered subcutaneously. Dosages range from 100-500 micrograms. A rescue shot is essentially a top-up to tackle breakthrough symptoms as quickly as possible (I have heard of some Lanreotide users also taking Octreotide rescue shots).
  • You can also ‘pump’ Octreotide using a switched on/off continuous infusion subcutaneously.
  • Other than for lab/trial use, to the best of my knowledge, there is no daily injection, rescue shot or ‘pump’ for Lanreotide that is indicated for patient use.
  • Whilst both have anti-tumour effects via studies, there are differences in US FDA approval: Octreotide (Sandostatin) is approved for symptom control (not anti-tumor) whereas Lanreotide (Somatuline) is approved for tumour control. However, the US FDA added a supplemental approval for Lanreotide syndrome control on the basis that it is proven to reduce the need for short-acting somatostatin analogues use – read more here.  This supplementary approval followed the ELECT trial – results here.  Read more about Lanreotide clinical trials here.   The study confirming the anti-tunour benefits of Octreotide can be found here
  • Octreotide has had many variants or ‘generics’ deployed over the years, Lanreotide variants only turned up in late 2021. Read more here.
  • Technical Article comparing both – click here or the picture below.

Technical Article comparing both – click here or the picture below.

Injection Administration

Always refer to the patient information leaflet as it is not safe to assume that all healthcare professionals are familiar with the administration.  Common issues include (but are not limited to): drug temperature requirements, injection site, pinching vs stretching skin, speed of injection.

Here are some interesting videos showing and explaining their administration:

Administering a Somatuline Depot (Lanreotide) injection:

click here or the picture below. This is the US version but the administration is the same anywhere.

Please note this is a US video thus the name Somatuline Depot rather than Autogel. Plus some of the rules regarding who and where the injection can take place may not apply to your country. Also any mention of approval wording may differ.

Administering a Sandostatin LAR (Octreotide) injection:

This link also provides guidance on the “new formulation” Octreotide.  Click here.

My own experience only includes daily injections of Octreotide (Sep-Nov 2010) and Lanreotide (Dec 2010 onwards).  I’ve also had continuous infusion of Octreotide in preparation for surgical or invasive procedures over the period 2010-2012 (i.e. crisis prevention).  You can read about my Lanreotide experience by clicking here.  If you are interested in what might be coming downstream, please see my blog entitled Somatostatin Analogues and Delivery Systems in the Pipeline’.

Injection site pain

I don’t really get much pain with Lanreotide and on a 10-point pain scale, I don’t think I would even score at 1. I believe there are a few factors for a successful injection in addition to the ones listed on the drug insert leaflets.  The experience and confidence of the person administering the injection (which includes adherence to the drug insert leaflet).  Secondly, a nervous patient who is unable to relax is most likely going to add to a degraded experience. 

However, I see many comments in my online patient support group, some report severe pain and some need cooling or pain reducing aids prior to the injection.  I think it is mostly tolerated though and the study below seems to confirm this. 

Nitya Raj, MD, clinical director, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, discusses the results of a phase 4 trial (NCT03289741) comparing injection site pain with octreotide long-acting release (LAR) vs lanreotide in well-differentiated neuroendocrine tumors (NETs).

The results of this randomized, blinded trial, which were presented during the 2021 NANETS Symposium, did not demonstrate a significant difference in the patient experience regarding comfort and pain with the injection with octreotide LAR vs lanreotide, Raj says. Among patients who received octreotide LAR first, the mean injection site pain score was 2.4 compared with 1.9 in patients who received lanreotide first, Raj explains.

The difference in these pain scores was not statistically significant, Raj continues. Moreover, it is important to recognize that out of a 10-point scale, the pain experienced by patients was relatively low overall, Raj concludes.  See video from Dr Raj here

Injection site granulomas (lumps)

The issue of ‘granulomas‘ or ‘injection site granulomas’ seems to figure in both drugs. Gluteal injection site granulomas are a very common finding on CT and plain radiographs. They occur as a result of subcutaneous (i.e. intra-lipomatous) rather than intramuscular injection of drugs, which cause localised fat necrosis, scar formation and dystrophic calcification. But no-one seems to know why they occur with somatostatin analogues.

Personally, I find that they are more conspicuous if the injection is done slightly too high which was my initial experience and they took months to fade.  I opted to stand up for the first two injections and I attribute this decision for a slightly too high injection site.  I now lie down which is actually recommended for the smaller and thinner patient. Although the lumps have reduced in size, I have not seen a new lump for some time indicating location might have been the cause. They sometimes show up on scans.  This is not a new problem and has been highlighted for the last 10 years in academic papers.  This particular paper is useful and the conclusion confirms this is not something that should worry patients too much. Read more here

Somatostatin Analogues and raised blood sugar levels

It is well documented that both Octreotide and Lanreotide can elevate blood glucose (sugar) levels.  Read more in my article Diabetes – the NET Effect.

Somatostatin Analogues and thyroid levels

It is well documented that both Octreotide and Lanreotide can mess with thyroid hormone levels. Read more in my article on Don’t be underactive with your Thyroid surveillance.

Click on the picture to read

People ask about other delivery methods, e.g. capsules etc, but nothing is yet approved.  There are several initiatives in the pipeline, and you can find details of these by clicking on the picture above. 

At Home Services

Many areas have ‘at home’ services, read here to see more.

Disclaimer

I am not a doctor or any form of medical professional, practitioner or counsellor. None of the information on my website, or linked to my website(s), or conveyed by me on any social media or presentation, should be interpreted as medical advice given or advised by me.  Neither should any post or comment made by a follower or member of my private group be assumed to be medical advice, even if that person is a healthcare professional as they are not members of the private group or followers of my sites in any official capacity.  Please also note that mention of a clinical service, trial/study or therapy does not constitute an endorsement of that service, trial/study or therapy by Ronny Allan, the information is provided for education and awareness purposes and/or related to Ronny Allan’s own patient experience. This element of the disclaimer includes any complementary medicine, non-prescription over the counter drugs and supplements such as vitamins and minerals.

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28 thoughts on “Somatostatin Analogues for Neuroendocrine Cancer: Lanreotide and Octreotide

    • Lanreotide was originally approved for an anti tumour effect. There’s some data to suggest that Octreotide also has an anti tumour effect. Both are approved for symptom control. Octreotide LAR and Sandostatin are the same thing.

  • Carolyn Gillies

    Had my first lanreotide injection 21st Jan for atypical lung carcinoid with metastatic lymph nodes. Diagnosed October 2019. Cant keep any food in at all since. Constant pale diarrhea and lots of wind. Should I be concerned?

  • Diana

    I’ve always wondered what the difference was i.e. what each one was for, but I’m still none-the-wiser…? you explain that they are analogues and how to administer them. But in what scenario/illness or set of symptoms are they for?
    I’m on octreotide and have no idea what lanreotide is for.
    (G1, GI NETs S4 with functioning carcinoid syndrome)
    thank you!

      • Diana

        ok thanks. (you don’t actually explicitly state this , but it’s implied).

        You’ve been on both, what in your opinion is better?
        my symptoms are flushing, diarrhoea sometimes. (Had right hemi-colectomy 2011, metastasises in liver.)
        thank you!
        (I’m sorry if this info is in other links, I’m just overwhelmed with emails & FB groups, I also read this at 2am. )
        cheers Diana

      • I haven’t done both on the monthly versions. I’ve always been on Lanreotide. Without wishing to appear bias, for sheer ease of use plus a self inject option, I think Lanreotide.

  • David Lockwood

    Bloody marvelous! Im so clear now.

    At the risk of sounding stupid, I was so confused and as for Sandostatin LAR – I have thought for the last few months that LAR stood for Lanreotide. Cant blame me?

    Nothing was clearly explained to me 3 months ago. I now know, with the help of a friend, who pointed me to your article that I am actually on Octreotide. Excellent article Ronny! I am getting all of this with help along the way. Best wishes and keep up the good work!

  • Laura pascarella

    My husband has had both the lanreotide and the sandostatin. With the lanreotide he had diarrhea for weeks but the shot did not hurt. So he just had the sandostatin and the shot hurt so bad he could hardly stand it. Which is the better of the two or what can help with the lanreotide? He took Imodium d. He does not want to do the sandostatin again.

    • difficult question Laura. Lanreotide is supposed to stop or reduce diarrhea not cause it – for most it does that. Perhaps there is another reason for the diarrhea? Did he have the diarrhea before Lanreotide, does he get any diarrhea with sandostatin, has he had any abdominal surgery?

  • Suzanne Thomas

    Thank you for this information, i stopped octreotide because of the side effects but i see you have been on lanreotide for years, i am going to try it as my tumors keep secreting fluid and I’m in the emergency rooms getting drained. How has it helped you with that?

    • Diana

      Hi Suzanne, may I ask what your symptoms were on octreotide? and why they were so bad?
      I’ve been on it since beginning of 2019, recently went up to 30mg.
      is there things to watch out for? like gall stones forming.. etc.
      All I have us constipation sometimes.
      thank you!
      Diana

  • Erika McCarthy

    Thanks Ronny for this succinct and understandable article. You do such great work for the NET community!

  • Well done as usual Ronny. I have been on Sandostatin LAR for over 5 years. For a while 30mg monthly, then 40mg monthly, then 40mg every three weeks. Finally after liver surgery in 2013 back to 40mg monthly and in 2015 30mg monthly. This was all for syndrome control. I am still on it. Two months ago we found that 5 out of 6 tumors in my liver had shrunk to invisibility. I believe that the Sando plus the liver surgery which removed one very large tumor are the reason for this.

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