No-carrier-added Lutetium-177 displays superior characteristics when compared to the carrier-added analogue. The specific activity of n.c.a. Lutetium-177 is up to 4 to 5 times higher and offers the best preconditions for an efficient radiolabeling reaction. The n.c.a. Lu-177 product is characterized by a significantly longer shelf life than the c.a. Lu-177 variant, which must be used immediately upon receipt. Furthermore, n.c.a. Lutetium-177 provides the highest achievable radionuclidic purity. In comparison, c.a. isotope contains up to 0.1% metastable Lutetium-177m. This long-lived radionuclide decays with a half-life of 160.1 days and requires costly management and storage of contaminated radioactive waste and waste water.
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