PARP inhibitors are a type of targeted cancer drug. They are a treatment for some women with ovarian cancer. They are also in trials as a treatment for other types of cancer. Olaparib, niraparib and rucaparib are all examples of PARP inhibitors.
How do PARP inhibitors work?
PARP is a protein (enzyme) found in our cells, It helps damaged cells to repair themselves. As a cancer treatment, PARP inhibitors stop the PARP from doing its repair work in cancer cells and the cell dies. Researchers first looked at these drugs in cancers that already had problems repairing cell damage. They focused on cancers with a change (or fault) in genes called BRCA.
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