Clinical Trial: PRRT and CAPTEM combination therapy

Updated 2026: 

A more recent, mature publication from the same Australian CONTROL NET programme has confirmed the earlier signal: combining PRRT with CAPTEM produces high response rates, particularly in pancreatic NETs, but at the cost of substantially increased haematologic toxicity and no clear, durable survival advantage strong enough to change guidelines.

Highlights

Interesting conclusion on Pancreatic NET:  “The efficacy of CAPTEM/PRRT in pNETs should be tested in a phase III trial”.

Update 2022:  Trial complete.  Results:

The final results of this trial were presented at ASCO 2022 where it was concluded as follows:

“CONTROL NETs is the first randomized trial to demonstrate efficacy for PRRT in pNETs, in addition to a standard of care. Extended follow up confirms durable CAPTEM/PRRT activity, with superior PFS in pNETs. Late haematologic toxicity was seen in both mNET PRRT arms but was not higher with additional CAPTEM. The activity of CAPTEM/PRRT in pNETs should be tested in the phase III setting” – click here to read the abstract.

Combination treatments are common in chemotherapy, but this trial was different as it effectively combined the use of different therapies both with their own toxicity risks, albeit low in each therapy type.

General Clinical Trials Disclaimer

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided in the clinical trials document. It’s very important to check the trial inclusion and exclusion criteria before making any contact.

Inclusion of any trial within this blog should not be taken as a recommendation by Ronny Allan.

Click here to enter Ronny’s Clinical Trials Archive

Click here and answer all questions to join my private Facebook group

Disclaimer

I am not a doctor or any form of medical professional, practitioner or counsellor. None of the information on my website, or linked to my website(s), or conveyed by me on any social media or presentation, should be interpreted as medical advice given or advised by me.

Neither should any post or comment made by a follower or member of my private group be assumed to be medical advice, even if that person is a healthcare professional.

Please also note that mention of a clinical service, trial/study or therapy does not constitute an endorsement of that service, trial/study or therapy by Ronny Allan, the information is provided for education and awareness purposes and/or related to Ronny Allan’s own patient experience. This element of the disclaimer includes any complementary medicine, non-prescription over the counter drugs and supplements such as vitamins and minerals.

Thanks for reading.

Ronny

I’m also active on Facebook. Like my page for even more news.

Check out my WEGO Health Awards

Check out my Glossary of Terms

Please Share this post for Neuroendocrine Cancer awareness and to help another patient