Rosacea – the NET Effect

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Around 2001, I started noticing some issues on my nose, particularly around the creases, an issue I still experience today. It normally starts with a stinging feeling, an indication I’m about to experience some sort of inflammation. What eventually happens is something which looks like a ‘whitehead’ which I now know to be a ‘pustule’. Sometimes there are multiples, and most are not normally bigger than 2mm, mostly smaller. These pustules nearly always disappear within a short period of time, normally after washing/showering, but they tend to leave reddish marks which eventually fade. Very infrequently, these pustules would appear on my chin. My nose is slightly discoloured and more reddish than the rest of my face since the issue started.

Shortly after I started experiencing this issue, a doctor diagnosed me with ‘mild rosacea‘. If this is a correct diagnosis, then I would appear to mainly have Subtype 2 or papulopustular (acne) rosacea (see breakdown of types below). I also have the minor irritation of a recurrent mild eczema inside my right outer ear which has run parallel to this issue (…. spookily).

For around two years, I was treated with a mixture of low dose oral antibiotics (tetracycline) and a skin medication known as metronidazole. This did clear up the issue, but it always returned, and I stopped the medication opting instead for a commercial product which I find works better. It doesn’t clear it 100% but I’ve learned to live with it as a long-term chronic condition. I looked at many Rosacea sites online and none of the pictures seemed to apply to me and I agree with my diagnosing doctor in terms of a ‘mild’ version.

I worked out early on the triggers were stress, when ‘run down’, and too long in the sun. There were possibly others. Stress was part and parcel of the work I was involved in, and it was at a time when I left my life in the military after 29 years and started a second career in industry (often I think in hindsight, I may have been overly stressed at the life change without realising it). Without any medical input, I decided to try to make sure I got sufficient vitamins and I now appear to get less coughs and colds then I used to. I now try to stay out of the direct sun. Other common triggers are listed on reputable sites and include alcohol, hot and cold weather, exercise, hot baths and spicy foods but I have to say some of these activities will cause many people who do not have rosacea to turn red-faced for a short time. I guess they mean it’s exacerbated in those with Rosacea.

What is Rosacea

A common skin condition, usually occurring on the face, which predominantly affects fair-skinned but may affect all skin types in people aged 40 to 60 years old. It is more common in women but when affecting men, it may be more severe. It is a chronic condition, and can persist for a long time and, in any individual, the severity tends to fluctuate. Rosacea tends to affect the cheeks, forehead, chin and nose, and is characterised by persistent redness caused by dilated blood vessels, small bumps and pus-filled spots similar to acne. There may also be uncomfortable inflammation of the surface of the eyes and eyelids. I found this site to be a very useful Rosacea reference.

Rosacea is sometimes classified into 4 subtypes that may overlap:

  • Subtype one, known as erythematotelangiectatic rosacea (ETR), is associated with facial redness, flushing, and visible blood vessels.
  • Subtype two, papulopustular (or acne) rosacea, is associated with acne-like breakouts, and often affects middle-aged women.
  • Subtype three, known as rhinophyma, is a rare form associated with the thickening of the skin on your nose. It usually affects men and is often accompanied by another subtype of rosacea.
  • Subtype four is known as the ocular rosacea, and its symptoms are centred on the eye area.

    I would say I have overlapping subtypes one and two but, in the latter, only due to some small bits of visible blood vessels (telangiesctasia) with zero facial redness and flushing. 

What causes rosacea?

The cause of rosacea is not fully understood. Your genetics, immune system factors, and environmental factors may all play a part. Factors that trigger rosacea cause the blood vessels in the skin of the face to enlarge (dilate). The theory that rosacea is due to bacteria on the skin or in the gut has not been proven. However, antibiotics have proven helpful to treat rosacea. This is because of their anti-inflammatory effect. Rosacea is not contagious.

Why is rosacea sometimes linked to NETs?

On certain sites and in certain texts about NETs, you will see mention of Rosacea, clearly as a misdiagnosis of someone who presents with flushing. I started experiencing the sensation of NET related flushing in late 2009/early 2010 and I can honestly say this was a totally different experience to what I had with my mild rosacea. However, I don’t have the ‘blushing’ type of rosacea and I can see the presentational similarities.

Another issue commonly reported in both conditions is small visible blood vessels on the face, known formally as Telangiectasia or informally as ‘spider veins’ or ‘broken capillary veins’. This is quite common with erythematotelangiectatic rosacea (subtype 1). I actually have at least two of these showing and this appears to be something I’ve only noticed since the NET diagnosis and only in the last few years. Interesting, it says this is something normally caused by “chronic flushing” but I wouldn’t have labelled my flushing in that way. I have not felt any flushing since late 2010 after surgery and the commencement of long-acting somatostatin analogues. Unless there has been something ‘sub-clinical’ going on, I’ve veered my minor issue towards long-term but mild rosacea as the cause rather than NETs. Telangiectasia is mentioned in many NET texts including my own article Neuroendocrine Cancer: A Witch’s Brew of Signs and Symptoms

Histamine if often linked to both conditions. Read about NET related to histamine here and Rosacea histamine issues here.

BUT …..  the only real link with substance is the fact that many NET flushing episodes may be thought to have been rosacea. 

on a good day.


Rosacea has similarities to many other skin conditions. In fact, skin issues seem to be pretty common with NET patients, I guess many are pretty much normal comorbidities which we all get but some might be linked to vitamin deficiencies or side effects of treatment. Some skin issues are actually directly linked to NETs including Merkel Cell Carcinoma, pellagra (linked to extreme cases of Carcinoid Syndrome) and Sweet’s syndrome (linked to Glucagonoma). 


I am not a doctor or any form of medical professional, practitioner or counsellor. None of the information on my website, or linked to my website(s), or conveyed by me on any social media or presentation, should be interpreted as medical advice given or advised by me. 

Neither should any post or comment made by a follower or member of my private group be assumed to be medical advice, even if that person is a healthcare professional.   

Please also note that mention of a clinical service, trial/study or therapy does not constitute an endorsement of that service, trial/study or therapy by Ronny Allan, the information is provided for education and awareness purposes and/or related to Ronny Allan’s own patient experience. This element of the disclaimer includes any complementary medicine, non-prescription over the counter drugs and supplements such as vitamins and minerals.

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7 thoughts on “Rosacea – the NET Effect

  • Maria

    I’ve been suffering with ‘Acne Rosacea’ for years now and it’s truly exhausting too navigate.
    I refuse to take anymore antibiotics. I’m doing a lot of research on my own terms now and I came across your article which is probably the most relatable one I have found yet.
    I’ve changed my diet, I’ve gone gluten and dairy free which in the last week I’ve seen a decrease in inflammation on my face.
    I’m keeping both a photo diary and written diary to keep track of flare ups and I will hopefully pin point the sources.
    Thanks for creating this page! To anyone else suffering with this I wish you all well!

  • I started with rosacea about 2003, completely out of the blue, never had a problem with it before, at one stage I was on the daily antibiotic for it. Then about 2012 I started getting little spots on my arms and thighs, just the occasional one, like a pimple. They were very itchy and would turn pink and rough, then leave little white scars. Then 12 months before my diagnosis I had a rash all over my upper torso which lasted about 4 months. I think it was all related to this, haven’t had the body rash since but still get out breaks outs of rosacea and the spots. I have some creams I use on them with no additives which help keep things under control.

  • Chris

    I had a similar problem for years, like you I was given antibiotics for Rosacea . Eventually diagnosed as Seborrhoeic Dematitis, mild and used Daktacort cream. It seems to have settled as I have got older, but just occasionally I get that tingly feeling in my nasal crease

  • Nice article Ronny. I’m developing skin issues which I’m surmising are related to my carcinoid syndrome. I get flushing nearly all day long and I also wake up in the morning with it. My face swells too. It effects my eyes as well. The skin in the areas that turn red are beginning to change and even a bit rashy looking in some areas. I can relate to your troubles. I’ve read that the flushing can lead to Rosacea and the pics they have, well for a woman are very scary. The red nose of an alcoholic is also similar. You aren’t tippling too much are you? God bless.

      • Okay, so you don’t drink. That’s good cause they said lay off the sauce while being treated for NETs. I hope my attempts at humor don’t put you off. I’m planning on laughing my way thru this cause if I start crying I’ll be in big trouble. Do you have carcinoid syndrome yet? I don’t think everyone gets it. I hope you don’t mind me prying. I’m trying to use various things on my rough patches. I sincerely hope it doesn’t become eczema. I’m also getting a few spider veins across my cheeks from the flushing. I read that they will go away when I’m not longer having the flushing. I can also get them lasered later on. It is a cosmetic thing but since it is from the CS, my insurance may pay for it. God bless.

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