5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors. The receptor 5-HT3 is related to nausea and sickness.
Ondansetron is a powerful anti-sickness drug given to cancer patients and some of you may recognise it as ZOFRON. Interestingly it’s a serotonin receptor (5-HT3) antagonist (5HT3-RA) for antineoplastic chemotherapy-induced nausea and vomiting. Ondansetron is a drug which blocks the 5-HT receptor, which is used to treat nausea and sickness, and has an excellent safety record. Other 5HT3-RAs include Tropisetron, Granisetron, Dolasetron, Palonosetron, Ramosetron (the group of drugs in the class known as 5HT3-RAs are known a ‘setrons’).
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