27 Mar 2026
By Ronny Allan
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Understanding Differentiation, Ki‑67, Mitotic Count, Hotspots, Pathology Workflow, and Primary–Metastasis Heterogeneity in Neuroendocrine Neoplasms (NENs)

Understanding Differentiation, Ki‑67, Mitotic Count, Hotspots, Pathology Workflow, and Primary–Metastasis Heterogeneity in Neuroendocrine Neoplasms (NENs)

Patient Advocacy, Treatment, , , , , ,
Before you read this… This article discusses pathology concepts such as Ki-67, grading, heterogeneity, and biopsy findings in neuroendocrine tumours (NETs). It is provided for educational purposes only and does not interpret any individual pathology report or scan result. Ki-67 values, tumour grade, and sampling limitations can vary between different biopsies and over time. Their meaning depends on the full clinical context, including imaging, symptoms, and multidisciplinary review. Only your own specialist team can explain what your specific Ki-67, grade, or pathology findings mean for you. No treatment decisions should be made based on this article alone. Neuroendocrine Neoplasms (NENs)…
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24 Jul 2025
By Ronny Allan
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My NET is different than yours

My NET is different than yours

A spotlight on NENs, Awareness, Living with Neuroendocrine Cancer, , , , , , ,
When you manage a large support group, you see a lot of posts.  Many of them highlight a lack of knowledge about the heterogeneity of Neuroendocrine Neoplasms.  The issue is not always with those answering the question but often it is the person asking the question.  Sometimes intervention is needed to focus responses. So, what are the key issues?   Read on..... If you read any authoritative source on this cancer, it will normally begin with “Neuroendocrine Neoplasms (NENs) are heterogeneous tumours ………….”  “Heterogeneous” means consisting of dissimilar parts or elements, essentially meaning “mixed” or “diverse,” but I used the term…
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04 Apr 2025
By Ronny Allan
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These 5 posts about Neuroendocrine Cancer are worth a read, see why inside

These 5 posts about Neuroendocrine Cancer are worth a read, see why inside

Newsletters, , ,
Sometimes I experiment with the layout, length and choice of words and graphics (particularly the latter) to see if a certain approach increases traffic and hits.  As a blogger, traffic and hits are important for motivation but for me, the message is always more important. I once wrote a blog in 30 minutes and it is currently still the most read blog and has been for years.  I adopted a Halloween theme for an awareness post called "Neuroendocrine Cancer – normally slow but always sneaky" I was amazed by the response, despite the quick and dirty output. I've written many…
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03 Feb 2025
By Ronny Allan
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If you don’t understand the heterogeneity of Neuroendocrine Neoplasms, it’s likely you don’t really understand Neuroendocrine Neoplasms

If you don’t understand the heterogeneity of Neuroendocrine Neoplasms, it’s likely you don’t really understand Neuroendocrine Neoplasms

Patient Advocacy,
If you read any authoritative source on this cancer, it will normally begin with “Neuroendocrine Neoplasms (NENs) are heterogeneous tumours ………….”. "Heterogeneous" means consisting of dissimilar parts or elements, essentially meaning "mixed" or "diverse," but I used the term "heterogeneity" to refer to the quality or state of being heterogeneous, meaning the presence of diverse components within a group or system; both terms indicate a lack of uniformity or consistency. You will note I used the term Neuroendocrine Neoplasms here - that is in line with formal naming conventional per agreed International Agency for Research on Cancer (IARC) terms.  It…
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