An inherited disease, which can result in tumours in the pituitary and parathyroid glands, and pancreas. Also called MEN1 syndrome, multiple endocrine adenomatosis, and multiple endocrine neoplasia type 1 syndrome.
MEN1 is caused by a defect in a gene called the MEN1 gene. This gene is found on Chromosome 11 and its job is to produce the protein menin. Faults or ‘spelling mistakes’ (mutations) in this gene have been found in over 90% of patients with MEN1; however, in some patients and their families with the condition, a gene fault still cannot be found. The mutations result in failure to produce the correct menin protein and the loss of the protein allows tumours to develop. Not every patient will have a family history of MEN1 as the mutation can arise anew in an individual.
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