Update 5th May 2026.
Biotechnology company MimiVax Inc. and Roswell Park Comprehensive Cancer Center today jointly announced the launch of a phase 2 clinical trial (NCT06202066) evaluating SurVaxM in combination with temozolomide in patients with progressing neuroendocrine tumours, also known as NETs. The study is being conducted at Roswell Park in Buffalo, New York, under the direction of principal investigator Dr. Jasmeet Kaur.
This trial has changed course. It started in 2021 as a phase 1 trial for NETs. A separate trial then added Temozolomide as a combo treatment. Then Phase 2 of the clinical trial gathered all the data and the original trial continues with the Temozolomide combo with SurVaxM but restricted to grade 3 patients i.e. well differentiated G3 NET and poorly differentiated Neuroendocrine Carcinoma (NEC).
What are cancer vaccines?
I remember seeing a comment by a NET Specialist on twitter saying, “We need vaccines”. This was in response to a tweet from another NET Specialist reporting dismal data from an immunotherapy drug for Neuroendocrine Carcinomas. In 2020/2021, the word vaccine has been used a lot, but this specialist was not inferring anti-viral treatment, he was talking about “cancer vaccines”, an emerging discipline in science where vaccines act as an immunostimulant to treat cancer. This prompted me to look around and found this trial which may be of interest to you. However, before anyone gets too excited, this is very early days in the study of SurVaxM in Neuroendocrine Cancer. The vaccine is also being trialled in in Malignant Glioma/gliomablastoma (brain tumours) and Multiple Myeloma (blood cancer).
What is SurVaxM?
SurVaxM is a first-of-its-kind, patented peptide mimic immunotherapeutic vaccine (immunotherapy) that targets survivin, a cell-survival protein present in 95 percent of glioblastomas and many other cancers. It is engineered to recognize survivin-expressing cancer cells as foreign and stimulate patients’ own immune response to control tumour growth and recurrence. While vaccines are typically thought of as ways to prevent diseases, vaccines can also be used in a therapeutic mode as an immunostimulant (e.g., to treat cancer). SurVaxM is delivered through simple subcutaneous injection. MimiVax is leading on this. It’s a privately held, clinical-stage biotechnology company focused on the development and commercialization of immunotherapeutic vaccines and targeted therapies for the treatment of cancer. Their proprietary product portfolio is based on technology licensed from Roswell Park Comprehensive Cancer Center that targets survivin, a cell-survival protein that is present in most cancers and rarely detectable in normal tissue. Their therapies are designed to stimulate immune responses to control tumour growth and recurrence. MimiVax has an exclusive license to globally commercialize SurVaxM, as well as an extensive worldwide patent portfolio for SurVaxM and other products in development.
What is this phase 2 trial?
This phase 2 trial studies these primary objectives:
- To determine the clinical efficacy (progression free survival [PFS]) of combining temozolomide and SVN53-67/M57-KLH peptide vaccine (SurVaxM) in patients with progressing NECs.***
- To evaluate the safety and toxicity of the study drug combination (temozolomide + SurVaxM) in patients with progressing NECs.***
*** I believe this must be a typo as the acceptance criteria clearly states “Measurable, pathologically confirmed diagnosis of neuroendocrine tumor of gastrointestinal, pancreatic, or thoracic origin with ki67>20% (well-differentiated G3 NETs) or neuroendocrine carcinoma of any origin excluding small cell lung carcinoma”
Always check the acceptance criteria (inclusion and exclusion criteria) on any clinical trial. You can find these at reference 3 below.
Any data from this trial?
Keep an eye on the resources below, particularly 5 and 6 below.
Read more here
Resource links here:
- Minivax Website: Click here
2. Clinical Trials Document Phase 1 NCT06202066: Click here
3. Clinical Trials Document Phase 2 – (as above – it has been amended)
4. Clinical Trials Document adding Temozolomide NCT03879694 (trial now closed)
5. NET Research Foundation coverage: Click here
6. Roswell Park Trial page: Click here
Worth noting this trial is in collaboration with Roswell Park Comprehensive Cancer Center (led by Dr Renuka Iyer), the US National Cancer Institute (NCI) and NET Research Foundation.
Also check out an excellent summary of the trial including a patient story and a video clip from Dr Iyer over on NET Research Foundation – click here
Click here to enter Ronny’s Clinical Trials Archive
General Clinical Trials Disclaimer
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided in the clinical trials document. It’s very important to check the trial inclusion and exclusion criteria before making any contact. If you need questions, the articles here is very useful Questions to Ask About Clinical Trials | Cancer.Net
The inclusion of any trial within this blog should not be taken as a recommendation by Ronny Allan.
Disclaimer
I am not a doctor or any form of medical professional, practitioner or counsellor. None of the information on my website, or linked to my website(s), or conveyed by me on any social media or presentation, should be interpreted as medical advice given or advised by me.
Neither should any post or comment made by a follower or member of my private group be assumed to be medical advice, even if that person is a healthcare professional.
Please also note that mention of a clinical service, trial/study or therapy does not constitute an endorsement of that service, trial/study or therapy by Ronny Allan, the information is provided for education and awareness purposes and/or related to Ronny Allan’s own patient experience. This element of the disclaimer includes any complementary medicine, non-prescription over the counter drugs and supplements such as vitamins and minerals.
Finally
Whenever I post about a trial or study, some people get excited without understanding that these new treatments and capabilities can very often take years to come to fruition and it’s also possible that clinical trials can be halted, or that national approval agencies will not approve the final product. Plus, not everyone will be eligible, so always check the exclusion and inclusion criteria in the relevant clinical trials document. Please bear that in mind when reading studies/clinical trials posted on RonnyAllan.NET
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It’s too late for my husband, the disease that had many options for treatment took him out on January 3, 2021. We were taken by surprise when we finally got back to UChicago Medicine, after treatment for his disease had to be put on hold due to Covid 19. He was diagnosed with Multiple Myleoma. Turns out the MM was aggressive and took presedence over the liver mets. After 10 weeks of treatment for MM he had a 50% improvement for that cancer. Unfortunately, there was nothing to offer the NET due to tumor growth and further damage to the liver from the MM chemo.
I will continue to follow progress for new treatments for NETS.
Thank you, Ronny for continuing to post.
Many blessings,
Juliette
So sorry to hear Juliette. Sincere condolences 🙏