Conventional PRRT (e.g. Lutathera, Lu177 Dotatate) is based on a somatostatin receptor ‘agonist’ approach, whereas 177Lu Ops 201 Satoreotide is a receptor ‘Antagonist’. The differences are quite technical but in the most layman terms , the antagonist has the capability of attaching (binding) to more receptors, including those in a ‘resting’ or ‘inactive’ state, spends more time on the tumour than agonist based therapies. The result is a higher number of receptor binding sites and greater tumour uptake. In addition it is said to show an improved tumour-to-kidney dose ratio compared to 177Lu-DOTA-TATE.
As at Apr 2020, this is in clinical trial stage. Read more here – click
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