NETs located in the duodenum are increasingly detected in early, easily treatable stages. Smaller tumours are mostly non-functional (hormone inactive) and usually do not cause any discomfort. Duodenal NETs are often found incidentally during a gastroscopy that is being carried out for other reasons. If duodenal NETs present with a hormonal hypersecretion syndrome (Zollinger-Ellison or carcinoid syndrome), the situation can be different with many presenting at more advanced stages. It is estimated that around a quarter of all NETs of the small intestine arise from the duodenum.
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