Tag: TPH1

TPH1 is mainly synthesized by enterochromaffin cells in the gut.

01 Sep 2024

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Telotristat Ethyl (XERMELO) – an oral treatment for Carcinoid Syndrome Diarrhea not adequately controlled by Somatostatin Analogues

Telotristat Ethyl (XERMELO) – an oral treatment for Carcinoid Syndrome Diarrhea not adequately controlled by Somatostatin Analogues

TreatmentCarcinoid crisis, Carcinoid heart disease, Carcinoid syndrome, Carcinoid tumour, Diarrhea, Hedinger syndrome, Neuroendocrine tumour (NET), Quality of LIfe (QoL), Serotonin, Somatostatin analogues, Telotristat ethyl (Xermelo), TPH1, TPH2, Tryptophan hydroxylase (TPH), Xermelo (Telotristat ethyl)

Republished and reformatted and reviewed 1st September 2024. Original published 31st March 2016. What is Telotristat Ethyl? Telotristat Ethyl is a significant introduction to the treatment of Carcinoid Syndrome diarrhea. It's the first addition to the standard of care in more than 16 years and the first time an oral syndrome treatment has been developed. The drug was previously known as Telotristat Etiprate but was changed to Ethyl in Oct 2016. 'Etiprate' was previously a truncation of 'ethyl hippurate'. The brand name is XERMELO® Who is the drug for? The drug may be of benefit to those whose carcinoid syndrome diarrhea is not adequately…

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29 Aug 2024

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Serotonin – the NET effect

Serotonin – the NET effect

Diet and Nutrition, Living with Neuroendocrine Cancer, Patient Advocacy, The NET Effect Series5-HIAA, 5-HT, 5-HTP, 5-Hydrotryptophan (5-HTP), 5-Hydroxyindoleacetic Acid (5-HIAA), 5-Hydroxytryptamine (5-HT), Antidepressant, Anxiety, Blood brain barrier (BBB), Bradykinin, Brain serotonin, Cancer anger, Carcinoid heart disease, Carcinoid rage, Carcinoid syndrome, Depression, Desmoplasia, Diarrhea, Dopamine, Endocrine, Flushing, Foregut, Hindgut, Histamine, Hormones, Monoamine oxidase inhibitors (MAOIs), NET syndromes, Neuroendocrine, Neurotransmitter, Norepinephrine, Nutrition, Oxitriptan, Prostaglandin, Selective Serotonin Reuptake Inhibitor (SSRI), Serotonin, Serotonin and norepinephrine reuptake inhibitor (SNRI), Serotonin syndrome, Serum serotonin, St. John's wort, Thorson-Bioerck syndrome, TPH1, TPH2, Tricyclic antidepressant, Tryptophan, Tryptophan hydroxylase (TPH)

Background I'd never heard of Serotonin until I was diagnosed with Neuroendocrine Cancer in 2010. It is frequently discussed, often with contrasting views from the respondents. One common assumption/question is that it is responsible for many things that can go wrong with Neuroendocrine Tumour (NET) patients who have serotonin-producing tumours. To a certain extent, that's true but statement such as "it's the hormones" is an easy assumption to make; or an easy answer to give in response to a complex set of circumstances. It's difficult to get a definitive answer and the science behind the behaviour of our hormones isn't…

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