Small tumours – big impact
June 20, 2026
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In oncology, a “small” tumour generally refers to a mass that is 2cm or less in diameter. Tumours under 1 cm are often described as
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Ronny Allan
Ronny Allan is a 3 x award-winning accredited patient leader advocating internationally for Neuroendocrine Cancer and all other cancer patients generally. Check out his Social Media accounts including Facebook, BlueSky, WhatsApp, Instagram and and X.
What is TraceNETTM
TraceNETTM is a a novel copper-based ‘radiodiagnostic’ for detecting neuroendocrine tumours (NET). The PET imaging agent candidate is the diagnostic component of NUCLIDIUM’s theranostic program, which comprises a true theranostic pair for diagnosing and treating NET patients, leveraging the company’s unique copper-based approach. The Phase 1 program for the diagnostic is the first step in its clinical development and is planned to commence in the first half of 2023.
Nuclidium’s TraceNETTM program aims to overcome key limitations of existing radiodiagnostics and their corresponding therapeutics by increasing the sensitivity and diagnostic accuracy of NET imaging, including detecting metastases, while reducing the radiation burden for the patient. The TraceNETTM diagnostic consists of an imaging radioisotope (61Cu) and a somatostatin receptor (SSTR) antagonist-targeting molecule that binds with high affinity and specificity to SSTRs overexpressed on the surface of most NET cells.
Trial Summary
NUCLIDIUM announced that the Neuroendocrine Tumors Research Foundation (NETRF) has selected the company and its collaboration partner the University Hospital Basel as recipients of its Investigator Award. The grant will support the initiation and execution of a Phase 1 clinical trial with TraceNETTM The Investigator Award is granted to one or two applicants each year and supports projects for two years.
The Phase 1 study will assess the safety, biodistribution, pharmacokinetics and dosimetry of TraceNETTM in NET patients. It will also analyse the performance of TraceNETTM in PET/CT imaging compared to 68Ga-DOTATOC, one of the current state-of-the-art imaging agents for the detection of NET in the same patients.
Why is this trial important?
As technology moves on, scientists must look for more efficient diagnostics and therapies for NET. Ga68 based PET scans were a revolution in NET diagnostics in the same way Peptide Receptor Radionuclide Therapy (PRRT) using Lutathera (Lu177) was in therapy. But Nuclidium’s ‘theranostic approach’ provides a copper-based platform enables an easy adjustment of each product candidate from a diagnostic to a therapeutic by simply exchanging 61Cu with 67Cu.
Read more here
Information is sparse but I will build up this post in due course
1. ClinicalTrials.gov Identifier – to follow (likely to be Switzerland initially)
2. NET Research Foundation announcement – to follow.
3. Nuclidium’s copper based theranostic platforms – click here
General Clinical Trials Disclaimer
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided in the clinical trials document. It’s very important to check the trial inclusion and exclusion criteria before making any contact. If you need questions, the articles here is very useful Questions to Ask About Clinical Trials | Cancer.Net
The inclusion of any trial within this blog should not be taken as a recommendation by Ronny Allan.
Disclaimer
I am not a doctor or any form of medical professional, practitioner or counsellor. None of the information on my website, or linked to my website(s), or conveyed by me on any social media or presentation, should be interpreted as medical advice given or advised by me. Neither should any post or comment made by a follower or member of my private group be assumed to be medical advice, even if that person is a healthcare professional as they are not members of the private group or followers of my sites in any official capacity. Please also note that mention of a clinical service, trial/study or therapy does not constitute an endorsement of that service, trial/study or therapy by Ronny Allan, the information is provided for education and awareness purposes and/or related to Ronny Allan’s own patient experience. This element of the disclaimer includes any complementary medicine, non-prescription over the counter drugs and supplements such as vitamins and minerals.
Finally
Whenever I post about a trial or study, some people get excited without understanding that these new treatments and capabilities can very often take years to come to fruition and it’s also possible that clinical trials can be halted, or that national approval agencies will not approve the final product. Plus, not everyone will be eligible, so always check the exclusion and inclusion criteria in the relevant clinical trials document. Please bear that in mind when reading studies/clinical trials posted on RonnyAllan.NET
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