A Spotlight on Lung Neuroendocrine Neoplasms

A Spotlight on Lung Neuroendocrine Neoplasms

A spotlight on NENs - Types, Awareness, Patient Advocacy, Spotlight on NENs - Types Series
WHO Classification of Tumours, 5th Edition, Volume 5: Thoracic TumoursThe aim of this spotlight is to provide a summary of the latest information on Lung Neuroendocrine Neoplasms (NEN) including the latest terminology, epidemiology data, and guidelines.   This follows the publication of the Thoracic WHO classification 5th edition (2021): terminology and criteria for neuroendocrine neoplasms (Blue Book).  This book has been anticipated to see if the panel compiling this follows the lead of the Gastroenteropancreatic Neuroendocrine Neoplasms (GEPNEN) editions issued in 2017 (Endocrine) and 2019 (Digestive systems) by removing the antiquated misnomer term ''Carcinoid" in line with the recommendations made by senior NEN doctors in 2020 to have commonality across all blue books. Neuroendocrine neoplasm update: toward universal nomenclature © 2020 Society for Endocrinology 2020, Guido Rindi and Frediano Inzani.I can tell…
Read More
Paraneoplastic Syndromes – the NET Effect

Paraneoplastic Syndromes – the NET Effect

Patient Advocacy, Survivorship, The NET Effect Series
Spectrum of paraneoplastic humoral syndromes secondary to NETs. CT, calcitonin; PTHrP, parathyroid hormone related peptide; CGRP, calcitonin gene related peptide; GLP, glucagon like peptide; ANP, atrial natriuretic peptide; VIP, vasointestinal peptide (*). Citation: Endocrine-Related Cancer 17, 3; 10.1677/ERC-10-0024 (* Author's note: not the usual description of VIP indicating a potential ectopic context) Although several hypotheses have been proposed regarding the pathogenesis of PNSs, the precise mechanism that leads to the development of PNS remains largely unknown. (In simple terms, pathogenesis means "the manner of development of a disease"Disclaimer. I read widely and noted various papers where there was clearly confusion about the classification of paraneoplastic in relation to Neuroendocrine Neoplasms.  Some papers grouped known Neuroendocrine Tumour hormonal syndromes in, but others were more specific by filtering these into ectopic scenarios. …
Read More